The creams are transdermal and designed to absorb through the skin into lymph nodes and then circulate throughout the lymphatic system. For this reason it is best to apply the cream to skin around lymph nodes closest to your region/s of concern. If your concern is non-topical or you are using for general immune boosting purposes, the best place to apply the cream is on either side of the lower neck region. More detailed instructions and a diagram is available on our instructions page here.