GcMAFplus® for anti-aging & skincare

Published On: 29 July 2021By

Is GcMAFplus® good for your skin?

The benefits of GcMAFplus® for cosmetic and antiaging purposes are often overshadowed by the other immune-related issues it is more commonly used for. We do understand that cosmetic benefit is not high on the list of priorities for a lot of our customers, however if you are seeking assistance in this area it might come as a surprise just how good our creams really are for your skin.

The GcMAFplus® (Glycoprotein-derived Macrophage Activating Factor) and other supporting ingredients in our creams are some of the most potent and effective ways to reverse the signs of ageing and make your skin look younger, healthier and glowing. It all comes down to our unique formula which delivers benefits much further than just skin-deep.

Reduces inflammation affecting skin health

As a macrophage activator, GcMAFplus® stimulates phagocytosis (immune response) of inflammatory cells. This is done in via anti-inflammatory macrophages (M2-like phenotypes). Inflammation plays a key role in the skin-aging process and is the leading cause of most dermatological issues including dermatitis, eczema, rosacea, psoriasis, dryness, hyperpigmentation and acne. Supplementing GcMAFplus® stimulates endogenous activation of macrophages into a homeostatic state capable of targeting and eradicating inflammation cells. This has immense benefit not just for managing dermatological conditions, but also making your skin look younger and healthier too.

Diagram of GcMAFplus® activating macrophage destroying inflammation

Being the largest organ in the body, the skin is one of the first places to show signs of chronic inflammation. Factors like sun exposure, environmental pollutants & contaminants, stress, a poor diet and even genetics, can all cause inflammation. This in turn causes premature ageing of the skin visible as fine lines, wrinkles, dryness, age spots, pigmentation and generally unhealthy looking skin. Using GcMAFplus® to stimulate macrophage response against inflammation is very effective to help prevent the ageing process and even reverse damage already done.

Helps fight free radicals and the effects of oxidative stress on skin

Your skin is a direct reflection of what is going on inside the body, especially metabolic. The presence of free radicals can cause oxidative stress from cellular damage. This in turn causes inflammation, impaired barrier function, loss of skin tissue and the destruction of collagen and elastin, both of which are essential for good skin health. Antioxidants are needed to nullify free radicals and help balance the body. Our creams contain numerous antioxidants, particularly Coenzyme Q10, which is one of the most powerful and beneficial antioxidants for healthy skin. This helps regulate free radicals, promoting collagen and elastin by minimizing the damage from oxidative stress.

Improves lymphatic system skin health

The lymphatic system greatly affects skin health and appearance. Located just below the skin and comprised of an intrinsic network of nodes and vessels, the lymphatic system is responsible for detoxing and cleansing the body, as well as maintaining fluid levels. If the lymphatic system is not functioning optimally, toxins, inflammation and other unwanted cellular debris will buildup causing the skin to become dry/blemished, lose elasticity, age prematurely and be prone to acne breakouts. This is where our GcMAFplus® creams come into their own. With a special low molecular-weight composition, the cream is absorbed through all 7 layers of the skin, delivering GcMAFplus® and other supporting ingredients into the lymphatic system. This helps heighten lymphatic function and allow the GcMAFplus® to activate the many macrophages housed within lymph fluid (white blood cells) responsible for fighting infection and damage to the skin.

Stimulates mitochondrial enzyme activity

Mitochondria energy production diagram

GcMAFplus® has been shown to increase mitochondrial enzyme activity (https://thescipub.com/pdf/ajisp.2013.120.129.pdf) In the skin, mitochondria are responsible for cell signalling, wound healing, pigmentation, vasculature homeostasis, and as one study by the Journal of Investigative Dermatology showed…

in human skin that with increasing age there is a specific decrease in the activity of a key metabolic enzyme found in the batteries of the skin cells. This enzyme is the hinge between the two important ways of making energy in our cells and a decrease in its activity contributes to decreased bio-energy in ageing skin.

Because GcMAFplus® stimulates mitochondrial enzyme production, this has the potential to bring benefit to skin health both directly and indirectly – particularly when considering that as we age mitochondrial activity decreases, thus allowing free radicals to prosper and increase their negative effect on skin via oxidative stress.

A powerful formula with ingredients designed to help…

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For Brightening

Vitamin C, Kakadu Plum Extract & Coenzyme Q10 are high in antioxidants and vitamins A, B1, B2, C, E, and K. These all help create a brighter, more youthful looking skin complexion.

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For Hydrating

Hyaluronan, jojoba oil, macadamia oil, avocado oil, cranberry extract & bilberry extract help maintain the skin’s moisture balance & a breathable barrier to gently prevent it from drying out.

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For Firming

Acetyl Hexapeptide-8 solution contains powerful peptides that target ageing on a cellular level to revitalize skin and bring a drastic reduction of the depth, density and surface area of wrinkles.


Other anti-aging skincare ingredients in our creams

In addition to GcMAF, our Original Range of creams contain other supporting ingredients proven to reverse the signs of ageing and promote better skin. These include:

Test tubes

Acetyl Hexapeptide-8 Solution

For anti-wrinkle, skin-smoothing and rejuvenation. These peptides are active ingredients containing Matrikines – peptide molecules which facilitate cutaneous restructuring and repair by activating the genes involved in the process of inter-cellular matrix renewal and cell proliferation. Through this activity, the Matrikines effectively restructure and smooth the surface and deeper layers of the skin, which results in a drastic reduction of the depth, density and surface area of wrinkles.


Hyaluronan (hyaluronic acid)

All GcMAFplus creams contain a low molecular-weight pharmaceutical-grade hyaluronan extracted from natural plant-based sources. Not only does this assist transdermal absorption through the skin, it also provides immense benefit to skin tone, hydration and elasticity. Hyaluronic acid is naturally-occurring in the body. It is found within the epidermis and keeps the skin hydrated and supple due to it’s high water retention ability. As we age our hyaluronan production naturally decreases and we begin to notice alterations in our skin such as wrinkling or dryness. Hyaluronan is therefore especially beneficial for mature people to replace what the body is no longer able to produce.

Vitamin C

Vitamin C Serum

Vitamin C a powerful antioxidant but it’s benefits don’t just stop there! Vitamin C also increases skin vitality and resilience by up-regulating collagen production. In our original range creams we have paired a stable, skin-compatible vitamin C with a range of ingredients that work together to brighten, hydrate and firm the skin.

CoEnzyme Q10

Coenzyme Q10 – certified organic

This powerful antioxidant is found naturally in our body, however as we age, our levels of CoQ10 decrease. The addition of the CoQ10 supplement to our creams help fights off ageing and leaves your skin glowing!

Does not contain harmful ingredients

What you don’t put on your skin is just as important as what you do put on. Many skincare products actually contain ingredients which cause inflammation, oxidative stress and other health issues. That is why all GcMAFplus creams DO NOT contain parabens, SLS, petrochemicals, silicones or any artificial colors or fragrances. These are all inflammatory or carcinogenic agent, and unfortunately found in a surprisingly large number of other common skincare products on the market.

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Frequently asked questions

Should I choose a cream from your natural or original range?

For cosmetic purposes we strongly recommend the creams from our Original range. These have many other additional ingredients specifically for skincare that our natural range of creams do not have.

What strength cream should I use for skincare?

This will depend on the nature of what you are trying to achieve and extent of damage to your skin. For a more intensive approach you can go with our higher strength creams, however for cosmetic purposes this is often superfluous. Unless you have significant skin damage or are addressing an aggressive dermatological condition, our less expensive medium strength or low strength creams will suffice. For more aggressive purposes our high strength and super strength creams are still perfectly safe to use for dermatological issues or general skincare, and may provide fast-tracked results.

How do I apply the creams for skincare?

Dispense 1 cream application (the size of a small pea) and rub in gently across the face (or affected region) AND your lower neck. It is important to apply a little to the neck because the lymph nodes here will help the formula absorb into your lymphatic system for best results. Make sure you do not get the cream in your eyes. Apply once or twice a day, after you shower is a good time. It is best to apply the cream before you use any other skin products to ensure it is absorbed fully into the skin and not blocked. Repeat daily ongoing or until desired results are achieved.

How long should I use the cream for?

It is perfectly fine to continue use of our creams ongoing, much like you would any other beauty or skincare product. Because the creams contain moisturizing, cleansing and protective ingredients, you can replace your other skincare products with our creams if desired. Used once a day 1 jar will last 70 days, or used twice a day 1 jar will last 35 days.

Choose from our original range creams for skincare…