How does it work?

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All GcMAFplus® products are made in an Australian GMP ISO22716 certified laboratory and tested to be 100% bioidentical to GcMAF naturally produced in the body.


Many people ask what does GcMAF do, does it activate the immune system? GcMAF (Gc Macrophage Activating Factor) is believed to activate immune cells, particularly macrophages. GcMAF’ s primary mechanism of action is centered around macrophage activation, which can lead to a cascade of immune responses. Macrophages are a type of white blood cell that plays a key role in the immune system’s defence against infections, pathogens, and abnormal cells.

When GcMAF activates macrophages, it enhances their ability to:

  1. Phagocytose:Macrophages become more efficient at engulfing and digesting pathogens, cellular debris, and foreign particles.
  2. Release Cytokines:Activated macrophages release signalling molecules called cytokines, which help regulate immune responses, attract other immune cells to the site of infection, and communicate with various components of the immune system.
  3. Antigen Presentation:Macrophages play a role in presenting antigens (molecular markers of pathogens) to other immune cells, such as T cells, to initiate targeted immune responses.
  4. Tissue Repair:Activated macrophages are involved in tissue repair and healing, contributing to the resolution of inflammation.

In addition to macrophages, GcMAF’ s activation of the immune system can indirectly influence other immune cell types, such as T cells (both helper T cells and cytotoxic T cells), natural killer (NK) cells, and dendritic cells. The immune-modulating effects of GcMAF’ s impact on macrophages can lead to a broader activation and coordination of the immune response.

However, it’s important to note that the exact mechanisms and interactions involved in GcMAF’ s effects on immune cells are complex.