The active GcMAF molecule (Macrophage Activating Factor) is created by enzymatically modifying vitamin D-binding protein (also known as Gc protein) — a naturally occurring protein found in many organisms. It contains three sugar side chains: Galactose, Sialic acid, and N-acetylgalactosamine (GalNAc).
Through enzymatic cleavage, Galactose and Sialic acid are removed, leaving GalNAc exposed — enabling the protein to bind to macrophage receptors and activate immune function.
This process is precise, controlled, and reproducible in laboratory settings.
GcMAF can be produced from various source materials that contain Gc protein, including:
- Human serum (academic research only)
- Bio -Dynamic Organic Bovine serum or purified protein substrate
- Yeast-based recombinant systems
- Engineered bacterial cultures (e.g. E. coli)
- Synthetic recombinant Gc protein
Regardless of origin, the final molecule is defined by its structure, not its source.
At GcMAFplus, we use a non-serum, bio-safe protein source — purified under pharmaceutical-grade conditions — to isolate pure, bioidentical GcMAF. Our product is free from colostrum, dairy, or blood residues and is suitable for global use.
